Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation
Identifieur interne : 005368 ( Main/Exploration ); précédent : 005367; suivant : 005369Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation
Auteurs : Jie Huang [États-Unis] ; Maria Sabater-Lleal [Suède] ; Folkert W. Asselbergs [Pays-Bas] ; David Tregouet [France] ; So-Youn Shin [Royaume-Uni] ; Jingzhong Ding [États-Unis] ; Jens Baumert [Allemagne] ; Tiphaine Oudot-Mellakh [France] ; Lasse Folkersen [Suède] ; Andrew D. Johnson [États-Unis] ; Nicholas L. Smith [États-Unis] ; Scott M. Williams ; Mohammad A. Ikram [Pays-Bas] ; Marcus E. Kleber [Allemagne] ; Diane M. Becker [États-Unis] ; Vinh Truong [France] ; Josyf C. Mychaleckyj [États-Unis] ; Weihong Tang [États-Unis] ; Qiong Yang [États-Unis] ; Bengt Sennblad [Suède] ; Jason H. Moore [États-Unis] ; Frances M. K. Williams [Royaume-Uni] ; Abbas Dehghan [Pays-Bas] ; Günther Silbernagel [Allemagne] ; Elisabeth M. C. Schrijvers [Pays-Bas] ; Shelly Smith [États-Unis] ; Mahir Karakas [Allemagne] ; Geoffrey H. Tofler [Australie] ; Angela Silveira [Suède] ; Gerjan J. Navis [Pays-Bas] ; Kurt Lohman [États-Unis] ; Ming-Huei Chen [États-Unis] ; Annette Peters [Allemagne] ; Anuj Goel [Royaume-Uni] ; Jemma C. Hopewell [Royaume-Uni] ; John C. Chambers [Royaume-Uni] ; Danish Saleheen [Pakistan, Royaume-Uni] ; Per Lundmark [Suède] ; Bruce M. Psaty [États-Unis] ; Rona J. Strawbridge [Suède] ; Bernhard O. Boehm [Allemagne] ; Angela M. Carter [Royaume-Uni] ; Christa Meisinger [Allemagne] ; John F. Peden [Royaume-Uni] ; Joshua C. Bis [États-Unis] ; Barbara Mcknight [États-Unis] ; John Öhrvik [Suède] ; Kent Taylor [États-Unis] ; Maria Grazia Franzosi [Italie] ; Udo Seedorf [Allemagne] ; Rory Collins [Royaume-Uni] ; Anders Franco-Cereceda [Suède] ; Ann-Christine Syv Nen [Suède] ; Alison H. Goodall [Royaume-Uni] ; Lisa R. Yanek [États-Unis] ; Mary Cushman [États-Unis] ; Martina Müller-Nurasyid [Allemagne] ; Aaron R. Folsom [États-Unis] ; Saonli Basu [États-Unis] ; Nena Matijevic ; Wiek H. Van Gilst [Pays-Bas] ; Jaspal S. Kooner [Royaume-Uni] ; Albert Hofman [Pays-Bas] ; John Danesh [Royaume-Uni] ; Robert Clarke [Royaume-Uni] ; James B. Meigs [États-Unis] ; Sekar Kathiresan [États-Unis] ; Muredach P. Reilly [États-Unis] ; Norman Klopp [Allemagne] ; Tamara B. Harris [États-Unis] ; Bernhard R. Winkelmann [Allemagne] ; Peter J. Grant [Royaume-Uni] ; Hans L. Hillege [Pays-Bas] ; Hugh Watkins [Royaume-Uni] ; Timothy D. Spector [Royaume-Uni] ; Lewis C. Becker [États-Unis] ; Russell P. Tracy [États-Unis] ; Winfried M Rz [Allemagne] ; Andre G. Uitterlinden [Pays-Bas] ; Per Eriksson [Suède] ; Francois Cambien [France] ; Pierre-Emmanuel Morange [France] ; Wolfgang Koenig [Allemagne] ; Nicole Soranzo [Royaume-Uni] ; Pim Van Der Harst [Pays-Bas] ; Yongmei Liu [États-Unis] ; Christopher J. O'Donnell [États-Unis] ; Anders Hamsten [Suède]Source :
- Blood [ 0006-4971 ] ; 2012.
Abstract
We conducted a genome-wide association study to identify novel associations between genetic variants and circulating plasminogen activator inhibitor-1 (PAI-1) concentration, and examined functional implications of variants and genes that were discovered. A discovery meta-analysis was performed in 19 599 subjects, followed by replication analysis of genome-wide significant (
Url:
DOI: 10.1182/blood-2012-06-436188
PubMed: 22990020
PubMed Central: 3520624
Affiliations:
- Allemagne, Australie, France, Italie, Pakistan, Pays-Bas, Royaume-Uni, Suède, États-Unis
- Angleterre, Angleterre de l'Est, Bade-Wurtemberg, Bavière, Californie, Caroline du Nord, District de Darmstadt, District de Fribourg-en-Brisgau, District de Haute-Bavière, District de Karlsruhe, District de Münster, District de Tübingen, East Middle Sweden, Grand Londres, Groningue (province), Hesse (Land), Hollande-Méridionale, Maryland, Massachusetts, Minnesota, New Hampshire, Nouvelle-Galles du Sud, Oxfordshire, Pennsylvanie, Provence-Alpes-Côte d'Azur, Rhénanie-du-Nord-Westphalie, Svealand, Utrecht (province), Vermont, Virginie, Washington (État), Île-de-France
- Cambridge, Francfort-sur-le-Main, Fribourg-en-Brisgau, Groningue, Leyde, Londres, Mannheim, Marseille, Munich, Münster, Oxford, Paris, Rotterdam, Stockholm, Sydney, Tübingen, Ulm, Uppsala, Utrecht
- Université Pierre-et-Marie-Curie, Université d'Oxford, Université d'Ulm, Université d'Uppsala, Université de Cambridge, Université de Sydney, Université de la Méditerranée
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Le document en format XML
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<author><name sortKey="Baumert, Jens" sort="Baumert, Jens" uniqKey="Baumert J" first="Jens" last="Baumert">Jens Baumert</name>
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<country xml:lang="fr">Pays-Bas</country>
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<affiliation wicri:level="3"><nlm:aff id="aff16">Department of Internal Medicine, Erasmus MC Medical Center, Rotterdam, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus MC Medical Center, Rotterdam</wicri:regionArea>
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<affiliation wicri:level="3"><nlm:aff id="aff18">Mannheim Institute of Public Health, Medical Faculty, University of Heidelberg, Mannheim, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Mannheim Institute of Public Health, Medical Faculty, University of Heidelberg, Mannheim</wicri:regionArea>
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<region type="district" nuts="2">District de Karlsruhe</region>
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<author><name sortKey="Becker, Diane M" sort="Becker, Diane M" uniqKey="Becker D" first="Diane M." last="Becker">Diane M. Becker</name>
<affiliation wicri:level="2"><nlm:aff id="aff19">Division of Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD;</nlm:aff>
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</placeName>
<wicri:cityArea>Division of Internal Medicine, Johns Hopkins School of Medicine, Baltimore</wicri:cityArea>
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<author><name sortKey="Truong, Vinh" sort="Truong, Vinh" uniqKey="Truong V" first="Vinh" last="Truong">Vinh Truong</name>
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<country xml:lang="fr">France</country>
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<settlement type="city">Paris</settlement>
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<orgName type="university">Université Pierre-et-Marie-Curie</orgName>
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<author><name sortKey="Mychaleckyj, Josyf C" sort="Mychaleckyj, Josyf C" uniqKey="Mychaleckyj J" first="Josyf C." last="Mychaleckyj">Josyf C. Mychaleckyj</name>
<affiliation wicri:level="2"><nlm:aff id="aff21">Center for Public Health Genomics, University of Virginia, Charlottesville, VA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Virginie</region>
</placeName>
<wicri:cityArea>Center for Public Health Genomics, University of Virginia, Charlottesville</wicri:cityArea>
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<author><name sortKey="Tang, Weihong" sort="Tang, Weihong" uniqKey="Tang W" first="Weihong" last="Tang">Weihong Tang</name>
<affiliation wicri:level="2"><nlm:aff id="aff22">Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>National Heart, Lung, and Blood Institute (NHBLI) Framingham Heart Study, Framingham</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff23">Department of Biostatistics, Boston University, Boston, MA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Biostatistics, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sennblad, Bengt" sort="Sennblad, Bengt" uniqKey="Sennblad B" first="Bengt" last="Sennblad">Bengt Sennblad</name>
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<country xml:lang="fr">Suède</country>
<wicri:regionArea>Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
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<author><name sortKey="Moore, Jason H" sort="Moore, Jason H" uniqKey="Moore J" first="Jason H." last="Moore">Jason H. Moore</name>
<affiliation wicri:level="2"><nlm:aff id="aff24">Department of Genetics and Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Hampshire</region>
</placeName>
<wicri:cityArea>Department of Genetics and Department of Community and Family Medicine, Dartmouth Medical School, Lebanon</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Williams, Frances M K" sort="Williams, Frances M K" uniqKey="Williams F" first="Frances M. K." last="Williams">Frances M. K. Williams</name>
<affiliation wicri:level="3"><nlm:aff id="aff25">Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research & Genetic Epidemiology, King's College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
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<author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name>
<affiliation wicri:level="3"><nlm:aff id="aff15">Department of Epidemiology, Erasmus Medical Center (MC) Medical Center, Rotterdam, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center (MC) Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff26">Netherlands Consortium for Healthy Aging, Leiden, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Silbernagel, Gunther" sort="Silbernagel, Gunther" uniqKey="Silbernagel G" first="Günther" last="Silbernagel">Günther Silbernagel</name>
<affiliation wicri:level="3"><nlm:aff id="aff27">Division of Endocrinology, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Department of Internal Medicine, Eberhard-Karls-University Tübingen, Tübingen, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Endocrinology, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Department of Internal Medicine, Eberhard-Karls-University Tübingen, Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schrijvers, Elisabeth M C" sort="Schrijvers, Elisabeth M C" uniqKey="Schrijvers E" first="Elisabeth M. C." last="Schrijvers">Elisabeth M. C. Schrijvers</name>
<affiliation wicri:level="3"><nlm:aff id="aff15">Department of Epidemiology, Erasmus Medical Center (MC) Medical Center, Rotterdam, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center (MC) Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff26">Netherlands Consortium for Healthy Aging, Leiden, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smith, Shelly" sort="Smith, Shelly" uniqKey="Smith S" first="Shelly" last="Smith">Shelly Smith</name>
<affiliation wicri:level="2"><nlm:aff id="aff28">Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Karakas, Mahir" sort="Karakas, Mahir" uniqKey="Karakas M" first="Mahir" last="Karakas">Mahir Karakas</name>
<affiliation wicri:level="3"><nlm:aff id="aff29">Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tofler, Geoffrey H" sort="Tofler, Geoffrey H" uniqKey="Tofler G" first="Geoffrey H." last="Tofler">Geoffrey H. Tofler</name>
<affiliation wicri:level="4"><nlm:aff id="aff30">Royal North Shore Hospital, University of Sydney, Sydney, Australia;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Royal North Shore Hospital, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Silveira, Angela" sort="Silveira, Angela" uniqKey="Silveira A" first="Angela" last="Silveira">Angela Silveira</name>
<affiliation wicri:level="3"><nlm:aff id="aff2">Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden;</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Navis, Gerjan J" sort="Navis, Gerjan J" uniqKey="Navis G" first="Gerjan J." last="Navis">Gerjan J. Navis</name>
<affiliation wicri:level="3"><nlm:aff id="aff31">Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lohman, Kurt" sort="Lohman, Kurt" uniqKey="Lohman K" first="Kurt" last="Lohman">Kurt Lohman</name>
<affiliation wicri:level="2"><nlm:aff id="aff32">Department of Biostatistical Sciences, Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Biostatistical Sciences, Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name>
<affiliation wicri:level="2"><nlm:aff id="aff23">Department of Biostatistics, Boston University, Boston, MA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Biostatistics, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name>
<affiliation wicri:level="4"><nlm:aff id="aff33">Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff34">Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Hopewell, Jemma C" sort="Hopewell, Jemma C" uniqKey="Hopewell J" first="Jemma C." last="Hopewell">Jemma C. Hopewell</name>
<affiliation wicri:level="4"><nlm:aff id="aff35">Clinical Trial Service Unit, University of Oxford, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Trial Service Unit, University of Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Chambers, John C" sort="Chambers, John C" uniqKey="Chambers J" first="John C." last="Chambers">John C. Chambers</name>
<affiliation wicri:level="3"><nlm:aff id="aff36">Epidemiology and Biostatistics, Imperial College, London, London, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Epidemiology and Biostatistics, Imperial College, London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff37">Cardiology, Ealing Hospital National Health Service (NHS) Trust, Middlesex, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cardiology, Ealing Hospital National Health Service (NHS) Trust, Middlesex</wicri:regionArea>
<wicri:noRegion>Middlesex</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Saleheen, Danish" sort="Saleheen, Danish" uniqKey="Saleheen D" first="Danish" last="Saleheen">Danish Saleheen</name>
<affiliation wicri:level="1"><nlm:aff id="aff38">Center for Non-Communicable Diseases Pakistan, Karachi, Pakistan;</nlm:aff>
<country xml:lang="fr">Pakistan</country>
<wicri:regionArea>Center for Non-Communicable Diseases Pakistan, Karachi</wicri:regionArea>
<wicri:noRegion>Karachi</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff39">Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lundmark, Per" sort="Lundmark, Per" uniqKey="Lundmark P" first="Per" last="Lundmark">Per Lundmark</name>
<affiliation wicri:level="4"><nlm:aff id="aff40">Molecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden;</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Molecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea>
<orgName type="university">Université d'Uppsala</orgName>
<placeName><settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name>
<affiliation wicri:level="2"><nlm:aff id="aff41">Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff42">Group Health Research Institute, Group Health Cooperative, Seattle, WA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Group Health Research Institute, Group Health Cooperative, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Strawbridge, Rona J" sort="Strawbridge, Rona J" uniqKey="Strawbridge R" first="Rona J." last="Strawbridge">Rona J. Strawbridge</name>
<affiliation wicri:level="3"><nlm:aff id="aff2">Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden;</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boehm, Bernhard O" sort="Boehm, Bernhard O" uniqKey="Boehm B" first="Bernhard O." last="Boehm">Bernhard O. Boehm</name>
<affiliation wicri:level="4"><nlm:aff id="aff43">Division of Endocrinology, Diabetes and Metabolism, Graduate School of Molecular Diabetology and Endocrinology, University of Ulm, Ulm, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Endocrinology, Diabetes and Metabolism, Graduate School of Molecular Diabetology and Endocrinology, University of Ulm, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Carter, Angela M" sort="Carter, Angela M" uniqKey="Carter A" first="Angela M." last="Carter">Angela M. Carter</name>
<affiliation wicri:level="1"><nlm:aff id="aff44">Division of Cardiovascular and Diabetes Research, Leeds University, Leeds, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Cardiovascular and Diabetes Research, Leeds University, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meisinger, Christa" sort="Meisinger, Christa" uniqKey="Meisinger C" first="Christa" last="Meisinger">Christa Meisinger</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Peden, John F" sort="Peden, John F" uniqKey="Peden J" first="John F." last="Peden">John F. Peden</name>
<affiliation wicri:level="4"><nlm:aff id="aff33">Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff34">Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name>
<affiliation wicri:level="2"><nlm:aff id="aff45">Department of Medicine, University of Washington, Seattle, WA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Washington, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name>
<affiliation wicri:level="2"><nlm:aff id="aff46">Department of Biostatistics, University of Washington, Seattle, WA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Department of Biostatistics, University of Washington, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ohrvik, John" sort="Ohrvik, John" uniqKey="Ohrvik J" first="John" last="Öhrvik">John Öhrvik</name>
<affiliation wicri:level="3"><nlm:aff id="aff2">Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden;</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Taylor, Kent" sort="Taylor, Kent" uniqKey="Taylor K" first="Kent" last="Taylor">Kent Taylor</name>
<affiliation wicri:level="2"><nlm:aff id="aff47">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Franzosi, Maria Grazia" sort="Franzosi, Maria Grazia" uniqKey="Franzosi M" first="Maria Grazia" last="Franzosi">Maria Grazia Franzosi</name>
<affiliation wicri:level="1"><nlm:aff id="aff48">Department of Cardiovascular Research, Istituto Mario Negri, Milano, Italy;</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Cardiovascular Research, Istituto Mario Negri, Milano</wicri:regionArea>
<wicri:noRegion>Milano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Seedorf, Udo" sort="Seedorf, Udo" uniqKey="Seedorf U" first="Udo" last="Seedorf">Udo Seedorf</name>
<affiliation wicri:level="3"><nlm:aff id="aff49">Gesellschaft für Arterioskleroseforschunge V, Leibniz-Institut für Arterioskleroseforschung an der Universität Münster (LIFA), Münster, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Gesellschaft für Arterioskleroseforschunge V, Leibniz-Institut für Arterioskleroseforschung an der Universität Münster (LIFA), Münster</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Münster</region>
<settlement type="city">Münster</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Collins, Rory" sort="Collins, Rory" uniqKey="Collins R" first="Rory" last="Collins">Rory Collins</name>
<affiliation wicri:level="4"><nlm:aff id="aff35">Clinical Trial Service Unit, University of Oxford, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Trial Service Unit, University of Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Franco Cereceda, Anders" sort="Franco Cereceda, Anders" uniqKey="Franco Cereceda A" first="Anders" last="Franco-Cereceda">Anders Franco-Cereceda</name>
<affiliation wicri:level="3"><nlm:aff id="aff50">Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden;</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Syv Nen, Ann Christine" sort="Syv Nen, Ann Christine" uniqKey="Syv Nen A" first="Ann-Christine" last="Syv Nen">Ann-Christine Syv Nen</name>
<affiliation wicri:level="4"><nlm:aff id="aff40">Molecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden;</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Molecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea>
<orgName type="university">Université d'Uppsala</orgName>
<placeName><settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Goodall, Alison H" sort="Goodall, Alison H" uniqKey="Goodall A" first="Alison H." last="Goodall">Alison H. Goodall</name>
<affiliation wicri:level="1"><nlm:aff id="aff51">Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Leicester</wicri:regionArea>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yanek, Lisa R" sort="Yanek, Lisa R" uniqKey="Yanek L" first="Lisa R." last="Yanek">Lisa R. Yanek</name>
<affiliation wicri:level="2"><nlm:aff id="aff19">Division of Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Division of Internal Medicine, Johns Hopkins School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cushman, Mary" sort="Cushman, Mary" uniqKey="Cushman M" first="Mary" last="Cushman">Mary Cushman</name>
<affiliation><nlm:aff id="aff52">Departments of Medicine and Pathology, University of Vermont, Burlington, VT; GeneSTAR:</nlm:aff>
<wicri:noCountry code="subfield">VT; GeneSTAR:</wicri:noCountry>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff53">Departments of Medicine and Pathology, University of Vermont, Burlington, VT;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Vermont</region>
</placeName>
<wicri:cityArea>Departments of Medicine and Pathology, University of Vermont, Burlington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name>
<affiliation wicri:level="1"><nlm:aff id="aff54">Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation><nlm:aff>NONE</nlm:aff>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff56">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität München, Munich, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität München, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R." last="Folsom">Aaron R. Folsom</name>
<affiliation wicri:level="2"><nlm:aff id="aff22">Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Basu, Saonli" sort="Basu, Saonli" uniqKey="Basu S" first="Saonli" last="Basu">Saonli Basu</name>
<affiliation wicri:level="2"><nlm:aff id="aff57">Division of Biostatistics, University of Minnesota, Minneapolis, MN;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Biostatistics, University of Minnesota, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Matijevic, Nena" sort="Matijevic, Nena" uniqKey="Matijevic N" first="Nena" last="Matijevic">Nena Matijevic</name>
<affiliation><nlm:aff id="aff58">Hemostasis Laboratory, University of Texas Health Science Center at Houston, Houston, TX; Cardiovascular Health Study:</nlm:aff>
<wicri:noCountry code="subfield">TX; Cardiovascular Health Study:</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Van Gilst, Wiek H" sort="Van Gilst, Wiek H" uniqKey="Van Gilst W" first="Wiek H." last="Van Gilst">Wiek H. Van Gilst</name>
<affiliation wicri:level="3"><nlm:aff id="aff59">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S." last="Kooner">Jaspal S. Kooner</name>
<affiliation wicri:level="1"><nlm:aff id="aff37">Cardiology, Ealing Hospital National Health Service (NHS) Trust, Middlesex, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cardiology, Ealing Hospital National Health Service (NHS) Trust, Middlesex</wicri:regionArea>
<wicri:noRegion>Middlesex</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3"><nlm:aff id="aff15">Department of Epidemiology, Erasmus Medical Center (MC) Medical Center, Rotterdam, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center (MC) Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff26">Netherlands Consortium for Healthy Aging, Leiden, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Danesh, John" sort="Danesh, John" uniqKey="Danesh J" first="John" last="Danesh">John Danesh</name>
<affiliation wicri:level="4"><nlm:aff id="aff39">Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name>
<affiliation wicri:level="4"><nlm:aff id="aff60">Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Trial Service Unit, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Meigs, James B" sort="Meigs, James B" uniqKey="Meigs J" first="James B." last="Meigs">James B. Meigs</name>
<affiliation wicri:level="2"><nlm:aff id="aff61">General Medicine Division, Massachusetts General Hospital, Boston, MA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>General Medicine Division, Massachusetts General Hospital, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff62">Department of Medicine at Harvard Medical School, Boston, MA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Medicine at Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kathiresan, Sekar" sort="Kathiresan, Sekar" uniqKey="Kathiresan S" first="Sekar" last="Kathiresan">Sekar Kathiresan</name>
<affiliation wicri:level="2"><nlm:aff id="aff63">Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, MA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston</wicri:cityArea>
</affiliation>
<affiliation><nlm:aff>NONE</nlm:aff>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff65">Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Reilly, Muredach P" sort="Reilly, Muredach P" uniqKey="Reilly M" first="Muredach P." last="Reilly">Muredach P. Reilly</name>
<affiliation wicri:level="2"><nlm:aff id="aff66">Cardiovascular Institute, the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Cardiovascular Institute, the Perelman School of Medicine at the University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Klopp, Norman" sort="Klopp, Norman" uniqKey="Klopp N" first="Norman" last="Klopp">Norman Klopp</name>
<affiliation wicri:level="1"><nlm:aff id="aff67">Division of Molecular Epidemiology, Helmholtz Zentrum München, German Resrarch Center for Environmental Health, Neuherberg, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Molecular Epidemiology, Helmholtz Zentrum München, German Resrarch Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name>
<affiliation wicri:level="2"><nlm:aff id="aff68">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Winkelmann, Bernhard R" sort="Winkelmann, Bernhard R" uniqKey="Winkelmann B" first="Bernhard R." last="Winkelmann">Bernhard R. Winkelmann</name>
<affiliation wicri:level="3"><nlm:aff id="aff69">Cardiology Team Sachsenhausen, Frankfurt am Main, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cardiology Team Sachsenhausen, Frankfurt am Main</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grant, Peter J" sort="Grant, Peter J" uniqKey="Grant P" first="Peter J." last="Grant">Peter J. Grant</name>
<affiliation wicri:level="1"><nlm:aff id="aff44">Division of Cardiovascular and Diabetes Research, Leeds University, Leeds, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Cardiovascular and Diabetes Research, Leeds University, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hillege, Hans L" sort="Hillege, Hans L" uniqKey="Hillege H" first="Hans L." last="Hillege">Hans L. Hillege</name>
<affiliation wicri:level="3"><nlm:aff id="aff59">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name>
<affiliation wicri:level="4"><nlm:aff id="aff33">Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff34">Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D." last="Spector">Timothy D. Spector</name>
<affiliation wicri:level="3"><nlm:aff id="aff25">Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research & Genetic Epidemiology, King's College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Becker, Lewis C" sort="Becker, Lewis C" uniqKey="Becker L" first="Lewis C." last="Becker">Lewis C. Becker</name>
<affiliation wicri:level="2"><nlm:aff id="aff70">Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Division of Cardiology, Johns Hopkins School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tracy, Russell P" sort="Tracy, Russell P" uniqKey="Tracy R" first="Russell P." last="Tracy">Russell P. Tracy</name>
<affiliation wicri:level="2"><nlm:aff id="aff71">Department of Pathology and Biochemistry, University of Vermont College of Medicine, Burlington, VT;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Vermont</region>
</placeName>
<wicri:cityArea>Department of Pathology and Biochemistry, University of Vermont College of Medicine, Burlington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="M Rz, Winfried" sort="M Rz, Winfried" uniqKey="M Rz W" first="Winfried" last="M Rz">Winfried M Rz</name>
<affiliation wicri:level="3"><nlm:aff id="aff18">Mannheim Institute of Public Health, Medical Faculty, University of Heidelberg, Mannheim, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Mannheim Institute of Public Health, Medical Faculty, University of Heidelberg, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff72">Synlab Academy, Mannheim, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Synlab Academy, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
<affiliation><nlm:aff id="aff73">Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz Austria;</nlm:aff>
<wicri:noCountry code="subfield">Graz Austria</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
<affiliation wicri:level="3"><nlm:aff id="aff16">Department of Internal Medicine, Erasmus MC Medical Center, Rotterdam, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus MC Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff26">Netherlands Consortium for Healthy Aging, Leiden, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eriksson, Per" sort="Eriksson, Per" uniqKey="Eriksson P" first="Per" last="Eriksson">Per Eriksson</name>
<affiliation wicri:level="3"><nlm:aff id="aff2">Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden;</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cambien, Francois" sort="Cambien, Francois" uniqKey="Cambien F" first="Francois" last="Cambien">Francois Cambien</name>
<affiliation wicri:level="4"><nlm:aff id="aff20">Inserm UMR_S 937, ICAN Institute, Université Pierre et Marie Curie (UPMC, Paris 06), Paris, France;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm UMR_S 937, ICAN Institute, Université Pierre et Marie Curie (UPMC, Paris 06), Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Pierre-et-Marie-Curie</orgName>
</affiliation>
</author>
<author><name sortKey="Morange, Pierre Emmanuel" sort="Morange, Pierre Emmanuel" uniqKey="Morange P" first="Pierre-Emmanuel" last="Morange">Pierre-Emmanuel Morange</name>
<affiliation wicri:level="4"><nlm:aff id="aff74">Inserm UMR_S 626, Université de la Méditerranée, Marseille, France;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm UMR_S 626, Université de la Méditerranée, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
<settlement type="city">Marseille</settlement>
</placeName>
<orgName type="university">Université de la Méditerranée</orgName>
</affiliation>
</author>
<author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name>
<affiliation wicri:level="3"><nlm:aff id="aff29">Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name>
<affiliation wicri:level="1"><nlm:aff id="aff7">Wellcome Trust Sanger Institute, Hinxton, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton</wicri:regionArea>
<wicri:noRegion>Hinxton</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff25">Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research & Genetic Epidemiology, King's College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name>
<affiliation wicri:level="3"><nlm:aff id="aff59">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name>
<affiliation wicri:level="2"><nlm:aff id="aff75">Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff76">Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="O Donnell, Christopher J" sort="O Donnell, Christopher J" uniqKey="O Donnell C" first="Christopher J." last="O'Donnell">Christopher J. O'Donnell</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">National Heart, Lung, and Blood Institute (NHBLI) Framingham Heart Study, Framingham, MA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>National Heart, Lung, and Blood Institute (NHBLI) Framingham Heart Study, Framingham</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff10">Division of Intramural Research, NHLBI, Bethesda, MD;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Division of Intramural Research, NHLBI, Bethesda</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff77">Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name>
<affiliation wicri:level="3"><nlm:aff id="aff2">Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden;</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22990020</idno>
<idno type="pmc">3520624</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520624</idno>
<idno type="RBID">PMC:3520624</idno>
<idno type="doi">10.1182/blood-2012-06-436188</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">001797</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation</title>
<author><name sortKey="Huang, Jie" sort="Huang, Jie" uniqKey="Huang J" first="Jie" last="Huang">Jie Huang</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">National Heart, Lung, and Blood Institute (NHBLI) Framingham Heart Study, Framingham, MA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>National Heart, Lung, and Blood Institute (NHBLI) Framingham Heart Study, Framingham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sabater Lleal, Maria" sort="Sabater Lleal, Maria" uniqKey="Sabater Lleal M" first="Maria" last="Sabater-Lleal">Maria Sabater-Lleal</name>
<affiliation wicri:level="3"><nlm:aff id="aff2">Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden;</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W." last="Asselbergs">Folkert W. Asselbergs</name>
<affiliation wicri:level="3"><nlm:aff id="aff3">Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
<affiliation><nlm:aff>NONE</nlm:aff>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff5">Department of Medical Genetics, University Medical Center, Utrecht, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Genetics, University Medical Center, Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tregouet, David" sort="Tregouet, David" uniqKey="Tregouet D" first="David" last="Tregouet">David Tregouet</name>
<affiliation wicri:level="4"><nlm:aff id="aff6">Inserm Unite Mixte de Recherche (UMR)_S 937, ICAN Institute, Université Pierre et Marie Curie (UPMC, Paris 06), Paris, France;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm Unite Mixte de Recherche (UMR)_S 937, ICAN Institute, Université Pierre et Marie Curie (UPMC, Paris 06), Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Pierre-et-Marie-Curie</orgName>
</affiliation>
</author>
<author><name sortKey="Shin, So Youn" sort="Shin, So Youn" uniqKey="Shin S" first="So-Youn" last="Shin">So-Youn Shin</name>
<affiliation wicri:level="1"><nlm:aff id="aff7">Wellcome Trust Sanger Institute, Hinxton, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton</wicri:regionArea>
<wicri:noRegion>Hinxton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ding, Jingzhong" sort="Ding, Jingzhong" uniqKey="Ding J" first="Jingzhong" last="Ding">Jingzhong Ding</name>
<affiliation wicri:level="2"><nlm:aff id="aff8">Sticht Center on Aging, Wake Forest University School of Medicine, Winston-Salem, NC;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Sticht Center on Aging, Wake Forest University School of Medicine, Winston-Salem</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Baumert, Jens" sort="Baumert, Jens" uniqKey="Baumert J" first="Jens" last="Baumert">Jens Baumert</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oudot Mellakh, Tiphaine" sort="Oudot Mellakh, Tiphaine" uniqKey="Oudot Mellakh T" first="Tiphaine" last="Oudot-Mellakh">Tiphaine Oudot-Mellakh</name>
<affiliation wicri:level="4"><nlm:aff id="aff6">Inserm Unite Mixte de Recherche (UMR)_S 937, ICAN Institute, Université Pierre et Marie Curie (UPMC, Paris 06), Paris, France;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm Unite Mixte de Recherche (UMR)_S 937, ICAN Institute, Université Pierre et Marie Curie (UPMC, Paris 06), Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Pierre-et-Marie-Curie</orgName>
</affiliation>
</author>
<author><name sortKey="Folkersen, Lasse" sort="Folkersen, Lasse" uniqKey="Folkersen L" first="Lasse" last="Folkersen">Lasse Folkersen</name>
<affiliation wicri:level="3"><nlm:aff id="aff2">Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden;</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D." last="Johnson">Andrew D. Johnson</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">National Heart, Lung, and Blood Institute (NHBLI) Framingham Heart Study, Framingham, MA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>National Heart, Lung, and Blood Institute (NHBLI) Framingham Heart Study, Framingham</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff10">Division of Intramural Research, NHLBI, Bethesda, MD;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Division of Intramural Research, NHLBI, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Smith, Nicholas L" sort="Smith, Nicholas L" uniqKey="Smith N" first="Nicholas L." last="Smith">Nicholas L. Smith</name>
<affiliation wicri:level="2"><nlm:aff id="aff11">Department of Epidemiology, University of Washington, Seattle, WA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, University of Washington, Seattle</wicri:cityArea>
</affiliation>
<affiliation><nlm:aff>NONE</nlm:aff>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff13">Seattle Epidemiologic Research and Information Center, VA Office of Research and Development, Seattle, WA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Seattle Epidemiologic Research and Information Center, VA Office of Research and Development, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Williams, Scott M" sort="Williams, Scott M" uniqKey="Williams S" first="Scott M." last="Williams">Scott M. Williams</name>
<affiliation><nlm:aff id="aff14">Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN; Rotterdam Study:</nlm:aff>
<wicri:noCountry code="subfield">TN; Rotterdam Study:</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ikram, Mohammad A" sort="Ikram, Mohammad A" uniqKey="Ikram M" first="Mohammad A." last="Ikram">Mohammad A. Ikram</name>
<affiliation wicri:level="3"><nlm:aff id="aff15">Department of Epidemiology, Erasmus Medical Center (MC) Medical Center, Rotterdam, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center (MC) Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff16">Department of Internal Medicine, Erasmus MC Medical Center, Rotterdam, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus MC Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E." last="Kleber">Marcus E. Kleber</name>
<affiliation wicri:level="3"><nlm:aff id="aff17">Ludwigshafen Risk and Cardiovascular Health (LURIC) Study Nonprofit LLC, Freiburg, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Ludwigshafen Risk and Cardiovascular Health (LURIC) Study Nonprofit LLC, Freiburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff18">Mannheim Institute of Public Health, Medical Faculty, University of Heidelberg, Mannheim, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Mannheim Institute of Public Health, Medical Faculty, University of Heidelberg, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Becker, Diane M" sort="Becker, Diane M" uniqKey="Becker D" first="Diane M." last="Becker">Diane M. Becker</name>
<affiliation wicri:level="2"><nlm:aff id="aff19">Division of Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Division of Internal Medicine, Johns Hopkins School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Truong, Vinh" sort="Truong, Vinh" uniqKey="Truong V" first="Vinh" last="Truong">Vinh Truong</name>
<affiliation wicri:level="4"><nlm:aff id="aff20">Inserm UMR_S 937, ICAN Institute, Université Pierre et Marie Curie (UPMC, Paris 06), Paris, France;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm UMR_S 937, ICAN Institute, Université Pierre et Marie Curie (UPMC, Paris 06), Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Pierre-et-Marie-Curie</orgName>
</affiliation>
</author>
<author><name sortKey="Mychaleckyj, Josyf C" sort="Mychaleckyj, Josyf C" uniqKey="Mychaleckyj J" first="Josyf C." last="Mychaleckyj">Josyf C. Mychaleckyj</name>
<affiliation wicri:level="2"><nlm:aff id="aff21">Center for Public Health Genomics, University of Virginia, Charlottesville, VA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Virginie</region>
</placeName>
<wicri:cityArea>Center for Public Health Genomics, University of Virginia, Charlottesville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tang, Weihong" sort="Tang, Weihong" uniqKey="Tang W" first="Weihong" last="Tang">Weihong Tang</name>
<affiliation wicri:level="2"><nlm:aff id="aff22">Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">National Heart, Lung, and Blood Institute (NHBLI) Framingham Heart Study, Framingham, MA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>National Heart, Lung, and Blood Institute (NHBLI) Framingham Heart Study, Framingham</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff23">Department of Biostatistics, Boston University, Boston, MA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Biostatistics, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sennblad, Bengt" sort="Sennblad, Bengt" uniqKey="Sennblad B" first="Bengt" last="Sennblad">Bengt Sennblad</name>
<affiliation wicri:level="3"><nlm:aff id="aff2">Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden;</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moore, Jason H" sort="Moore, Jason H" uniqKey="Moore J" first="Jason H." last="Moore">Jason H. Moore</name>
<affiliation wicri:level="2"><nlm:aff id="aff24">Department of Genetics and Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Hampshire</region>
</placeName>
<wicri:cityArea>Department of Genetics and Department of Community and Family Medicine, Dartmouth Medical School, Lebanon</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Williams, Frances M K" sort="Williams, Frances M K" uniqKey="Williams F" first="Frances M. K." last="Williams">Frances M. K. Williams</name>
<affiliation wicri:level="3"><nlm:aff id="aff25">Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research & Genetic Epidemiology, King's College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name>
<affiliation wicri:level="3"><nlm:aff id="aff15">Department of Epidemiology, Erasmus Medical Center (MC) Medical Center, Rotterdam, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center (MC) Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff26">Netherlands Consortium for Healthy Aging, Leiden, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Silbernagel, Gunther" sort="Silbernagel, Gunther" uniqKey="Silbernagel G" first="Günther" last="Silbernagel">Günther Silbernagel</name>
<affiliation wicri:level="3"><nlm:aff id="aff27">Division of Endocrinology, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Department of Internal Medicine, Eberhard-Karls-University Tübingen, Tübingen, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Endocrinology, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Department of Internal Medicine, Eberhard-Karls-University Tübingen, Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schrijvers, Elisabeth M C" sort="Schrijvers, Elisabeth M C" uniqKey="Schrijvers E" first="Elisabeth M. C." last="Schrijvers">Elisabeth M. C. Schrijvers</name>
<affiliation wicri:level="3"><nlm:aff id="aff15">Department of Epidemiology, Erasmus Medical Center (MC) Medical Center, Rotterdam, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center (MC) Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff26">Netherlands Consortium for Healthy Aging, Leiden, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smith, Shelly" sort="Smith, Shelly" uniqKey="Smith S" first="Shelly" last="Smith">Shelly Smith</name>
<affiliation wicri:level="2"><nlm:aff id="aff28">Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Karakas, Mahir" sort="Karakas, Mahir" uniqKey="Karakas M" first="Mahir" last="Karakas">Mahir Karakas</name>
<affiliation wicri:level="3"><nlm:aff id="aff29">Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tofler, Geoffrey H" sort="Tofler, Geoffrey H" uniqKey="Tofler G" first="Geoffrey H." last="Tofler">Geoffrey H. Tofler</name>
<affiliation wicri:level="4"><nlm:aff id="aff30">Royal North Shore Hospital, University of Sydney, Sydney, Australia;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Royal North Shore Hospital, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Silveira, Angela" sort="Silveira, Angela" uniqKey="Silveira A" first="Angela" last="Silveira">Angela Silveira</name>
<affiliation wicri:level="3"><nlm:aff id="aff2">Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden;</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Navis, Gerjan J" sort="Navis, Gerjan J" uniqKey="Navis G" first="Gerjan J." last="Navis">Gerjan J. Navis</name>
<affiliation wicri:level="3"><nlm:aff id="aff31">Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lohman, Kurt" sort="Lohman, Kurt" uniqKey="Lohman K" first="Kurt" last="Lohman">Kurt Lohman</name>
<affiliation wicri:level="2"><nlm:aff id="aff32">Department of Biostatistical Sciences, Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Biostatistical Sciences, Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name>
<affiliation wicri:level="2"><nlm:aff id="aff23">Department of Biostatistics, Boston University, Boston, MA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Biostatistics, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name>
<affiliation wicri:level="4"><nlm:aff id="aff33">Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff34">Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Hopewell, Jemma C" sort="Hopewell, Jemma C" uniqKey="Hopewell J" first="Jemma C." last="Hopewell">Jemma C. Hopewell</name>
<affiliation wicri:level="4"><nlm:aff id="aff35">Clinical Trial Service Unit, University of Oxford, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Trial Service Unit, University of Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Chambers, John C" sort="Chambers, John C" uniqKey="Chambers J" first="John C." last="Chambers">John C. Chambers</name>
<affiliation wicri:level="3"><nlm:aff id="aff36">Epidemiology and Biostatistics, Imperial College, London, London, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Epidemiology and Biostatistics, Imperial College, London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff37">Cardiology, Ealing Hospital National Health Service (NHS) Trust, Middlesex, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cardiology, Ealing Hospital National Health Service (NHS) Trust, Middlesex</wicri:regionArea>
<wicri:noRegion>Middlesex</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Saleheen, Danish" sort="Saleheen, Danish" uniqKey="Saleheen D" first="Danish" last="Saleheen">Danish Saleheen</name>
<affiliation wicri:level="1"><nlm:aff id="aff38">Center for Non-Communicable Diseases Pakistan, Karachi, Pakistan;</nlm:aff>
<country xml:lang="fr">Pakistan</country>
<wicri:regionArea>Center for Non-Communicable Diseases Pakistan, Karachi</wicri:regionArea>
<wicri:noRegion>Karachi</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff39">Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lundmark, Per" sort="Lundmark, Per" uniqKey="Lundmark P" first="Per" last="Lundmark">Per Lundmark</name>
<affiliation wicri:level="4"><nlm:aff id="aff40">Molecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden;</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Molecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea>
<orgName type="university">Université d'Uppsala</orgName>
<placeName><settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name>
<affiliation wicri:level="2"><nlm:aff id="aff41">Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff42">Group Health Research Institute, Group Health Cooperative, Seattle, WA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Group Health Research Institute, Group Health Cooperative, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Strawbridge, Rona J" sort="Strawbridge, Rona J" uniqKey="Strawbridge R" first="Rona J." last="Strawbridge">Rona J. Strawbridge</name>
<affiliation wicri:level="3"><nlm:aff id="aff2">Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden;</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boehm, Bernhard O" sort="Boehm, Bernhard O" uniqKey="Boehm B" first="Bernhard O." last="Boehm">Bernhard O. Boehm</name>
<affiliation wicri:level="4"><nlm:aff id="aff43">Division of Endocrinology, Diabetes and Metabolism, Graduate School of Molecular Diabetology and Endocrinology, University of Ulm, Ulm, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Endocrinology, Diabetes and Metabolism, Graduate School of Molecular Diabetology and Endocrinology, University of Ulm, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Carter, Angela M" sort="Carter, Angela M" uniqKey="Carter A" first="Angela M." last="Carter">Angela M. Carter</name>
<affiliation wicri:level="1"><nlm:aff id="aff44">Division of Cardiovascular and Diabetes Research, Leeds University, Leeds, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Cardiovascular and Diabetes Research, Leeds University, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meisinger, Christa" sort="Meisinger, Christa" uniqKey="Meisinger C" first="Christa" last="Meisinger">Christa Meisinger</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Peden, John F" sort="Peden, John F" uniqKey="Peden J" first="John F." last="Peden">John F. Peden</name>
<affiliation wicri:level="4"><nlm:aff id="aff33">Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff34">Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name>
<affiliation wicri:level="2"><nlm:aff id="aff45">Department of Medicine, University of Washington, Seattle, WA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Washington, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name>
<affiliation wicri:level="2"><nlm:aff id="aff46">Department of Biostatistics, University of Washington, Seattle, WA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Department of Biostatistics, University of Washington, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ohrvik, John" sort="Ohrvik, John" uniqKey="Ohrvik J" first="John" last="Öhrvik">John Öhrvik</name>
<affiliation wicri:level="3"><nlm:aff id="aff2">Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden;</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Taylor, Kent" sort="Taylor, Kent" uniqKey="Taylor K" first="Kent" last="Taylor">Kent Taylor</name>
<affiliation wicri:level="2"><nlm:aff id="aff47">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Franzosi, Maria Grazia" sort="Franzosi, Maria Grazia" uniqKey="Franzosi M" first="Maria Grazia" last="Franzosi">Maria Grazia Franzosi</name>
<affiliation wicri:level="1"><nlm:aff id="aff48">Department of Cardiovascular Research, Istituto Mario Negri, Milano, Italy;</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Cardiovascular Research, Istituto Mario Negri, Milano</wicri:regionArea>
<wicri:noRegion>Milano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Seedorf, Udo" sort="Seedorf, Udo" uniqKey="Seedorf U" first="Udo" last="Seedorf">Udo Seedorf</name>
<affiliation wicri:level="3"><nlm:aff id="aff49">Gesellschaft für Arterioskleroseforschunge V, Leibniz-Institut für Arterioskleroseforschung an der Universität Münster (LIFA), Münster, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Gesellschaft für Arterioskleroseforschunge V, Leibniz-Institut für Arterioskleroseforschung an der Universität Münster (LIFA), Münster</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Münster</region>
<settlement type="city">Münster</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Collins, Rory" sort="Collins, Rory" uniqKey="Collins R" first="Rory" last="Collins">Rory Collins</name>
<affiliation wicri:level="4"><nlm:aff id="aff35">Clinical Trial Service Unit, University of Oxford, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Trial Service Unit, University of Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Franco Cereceda, Anders" sort="Franco Cereceda, Anders" uniqKey="Franco Cereceda A" first="Anders" last="Franco-Cereceda">Anders Franco-Cereceda</name>
<affiliation wicri:level="3"><nlm:aff id="aff50">Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden;</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Syv Nen, Ann Christine" sort="Syv Nen, Ann Christine" uniqKey="Syv Nen A" first="Ann-Christine" last="Syv Nen">Ann-Christine Syv Nen</name>
<affiliation wicri:level="4"><nlm:aff id="aff40">Molecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden;</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Molecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea>
<orgName type="university">Université d'Uppsala</orgName>
<placeName><settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Goodall, Alison H" sort="Goodall, Alison H" uniqKey="Goodall A" first="Alison H." last="Goodall">Alison H. Goodall</name>
<affiliation wicri:level="1"><nlm:aff id="aff51">Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Leicester</wicri:regionArea>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yanek, Lisa R" sort="Yanek, Lisa R" uniqKey="Yanek L" first="Lisa R." last="Yanek">Lisa R. Yanek</name>
<affiliation wicri:level="2"><nlm:aff id="aff19">Division of Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Division of Internal Medicine, Johns Hopkins School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cushman, Mary" sort="Cushman, Mary" uniqKey="Cushman M" first="Mary" last="Cushman">Mary Cushman</name>
<affiliation><nlm:aff id="aff52">Departments of Medicine and Pathology, University of Vermont, Burlington, VT; GeneSTAR:</nlm:aff>
<wicri:noCountry code="subfield">VT; GeneSTAR:</wicri:noCountry>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff53">Departments of Medicine and Pathology, University of Vermont, Burlington, VT;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Vermont</region>
</placeName>
<wicri:cityArea>Departments of Medicine and Pathology, University of Vermont, Burlington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name>
<affiliation wicri:level="1"><nlm:aff id="aff54">Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation><nlm:aff>NONE</nlm:aff>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff56">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität München, Munich, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität München, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R." last="Folsom">Aaron R. Folsom</name>
<affiliation wicri:level="2"><nlm:aff id="aff22">Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Basu, Saonli" sort="Basu, Saonli" uniqKey="Basu S" first="Saonli" last="Basu">Saonli Basu</name>
<affiliation wicri:level="2"><nlm:aff id="aff57">Division of Biostatistics, University of Minnesota, Minneapolis, MN;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Biostatistics, University of Minnesota, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Matijevic, Nena" sort="Matijevic, Nena" uniqKey="Matijevic N" first="Nena" last="Matijevic">Nena Matijevic</name>
<affiliation><nlm:aff id="aff58">Hemostasis Laboratory, University of Texas Health Science Center at Houston, Houston, TX; Cardiovascular Health Study:</nlm:aff>
<wicri:noCountry code="subfield">TX; Cardiovascular Health Study:</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Van Gilst, Wiek H" sort="Van Gilst, Wiek H" uniqKey="Van Gilst W" first="Wiek H." last="Van Gilst">Wiek H. Van Gilst</name>
<affiliation wicri:level="3"><nlm:aff id="aff59">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S." last="Kooner">Jaspal S. Kooner</name>
<affiliation wicri:level="1"><nlm:aff id="aff37">Cardiology, Ealing Hospital National Health Service (NHS) Trust, Middlesex, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cardiology, Ealing Hospital National Health Service (NHS) Trust, Middlesex</wicri:regionArea>
<wicri:noRegion>Middlesex</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3"><nlm:aff id="aff15">Department of Epidemiology, Erasmus Medical Center (MC) Medical Center, Rotterdam, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center (MC) Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff26">Netherlands Consortium for Healthy Aging, Leiden, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Danesh, John" sort="Danesh, John" uniqKey="Danesh J" first="John" last="Danesh">John Danesh</name>
<affiliation wicri:level="4"><nlm:aff id="aff39">Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name>
<affiliation wicri:level="4"><nlm:aff id="aff60">Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Trial Service Unit, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Meigs, James B" sort="Meigs, James B" uniqKey="Meigs J" first="James B." last="Meigs">James B. Meigs</name>
<affiliation wicri:level="2"><nlm:aff id="aff61">General Medicine Division, Massachusetts General Hospital, Boston, MA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>General Medicine Division, Massachusetts General Hospital, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff62">Department of Medicine at Harvard Medical School, Boston, MA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Medicine at Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kathiresan, Sekar" sort="Kathiresan, Sekar" uniqKey="Kathiresan S" first="Sekar" last="Kathiresan">Sekar Kathiresan</name>
<affiliation wicri:level="2"><nlm:aff id="aff63">Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, MA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston</wicri:cityArea>
</affiliation>
<affiliation><nlm:aff>NONE</nlm:aff>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff65">Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Reilly, Muredach P" sort="Reilly, Muredach P" uniqKey="Reilly M" first="Muredach P." last="Reilly">Muredach P. Reilly</name>
<affiliation wicri:level="2"><nlm:aff id="aff66">Cardiovascular Institute, the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Cardiovascular Institute, the Perelman School of Medicine at the University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Klopp, Norman" sort="Klopp, Norman" uniqKey="Klopp N" first="Norman" last="Klopp">Norman Klopp</name>
<affiliation wicri:level="1"><nlm:aff id="aff67">Division of Molecular Epidemiology, Helmholtz Zentrum München, German Resrarch Center for Environmental Health, Neuherberg, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Molecular Epidemiology, Helmholtz Zentrum München, German Resrarch Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name>
<affiliation wicri:level="2"><nlm:aff id="aff68">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Winkelmann, Bernhard R" sort="Winkelmann, Bernhard R" uniqKey="Winkelmann B" first="Bernhard R." last="Winkelmann">Bernhard R. Winkelmann</name>
<affiliation wicri:level="3"><nlm:aff id="aff69">Cardiology Team Sachsenhausen, Frankfurt am Main, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cardiology Team Sachsenhausen, Frankfurt am Main</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grant, Peter J" sort="Grant, Peter J" uniqKey="Grant P" first="Peter J." last="Grant">Peter J. Grant</name>
<affiliation wicri:level="1"><nlm:aff id="aff44">Division of Cardiovascular and Diabetes Research, Leeds University, Leeds, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Cardiovascular and Diabetes Research, Leeds University, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hillege, Hans L" sort="Hillege, Hans L" uniqKey="Hillege H" first="Hans L." last="Hillege">Hans L. Hillege</name>
<affiliation wicri:level="3"><nlm:aff id="aff59">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name>
<affiliation wicri:level="4"><nlm:aff id="aff33">Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff34">Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D." last="Spector">Timothy D. Spector</name>
<affiliation wicri:level="3"><nlm:aff id="aff25">Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research & Genetic Epidemiology, King's College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Becker, Lewis C" sort="Becker, Lewis C" uniqKey="Becker L" first="Lewis C." last="Becker">Lewis C. Becker</name>
<affiliation wicri:level="2"><nlm:aff id="aff70">Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Division of Cardiology, Johns Hopkins School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tracy, Russell P" sort="Tracy, Russell P" uniqKey="Tracy R" first="Russell P." last="Tracy">Russell P. Tracy</name>
<affiliation wicri:level="2"><nlm:aff id="aff71">Department of Pathology and Biochemistry, University of Vermont College of Medicine, Burlington, VT;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Vermont</region>
</placeName>
<wicri:cityArea>Department of Pathology and Biochemistry, University of Vermont College of Medicine, Burlington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="M Rz, Winfried" sort="M Rz, Winfried" uniqKey="M Rz W" first="Winfried" last="M Rz">Winfried M Rz</name>
<affiliation wicri:level="3"><nlm:aff id="aff18">Mannheim Institute of Public Health, Medical Faculty, University of Heidelberg, Mannheim, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Mannheim Institute of Public Health, Medical Faculty, University of Heidelberg, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff72">Synlab Academy, Mannheim, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Synlab Academy, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
<affiliation><nlm:aff id="aff73">Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz Austria;</nlm:aff>
<wicri:noCountry code="subfield">Graz Austria</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
<affiliation wicri:level="3"><nlm:aff id="aff16">Department of Internal Medicine, Erasmus MC Medical Center, Rotterdam, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus MC Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff26">Netherlands Consortium for Healthy Aging, Leiden, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eriksson, Per" sort="Eriksson, Per" uniqKey="Eriksson P" first="Per" last="Eriksson">Per Eriksson</name>
<affiliation wicri:level="3"><nlm:aff id="aff2">Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden;</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cambien, Francois" sort="Cambien, Francois" uniqKey="Cambien F" first="Francois" last="Cambien">Francois Cambien</name>
<affiliation wicri:level="4"><nlm:aff id="aff20">Inserm UMR_S 937, ICAN Institute, Université Pierre et Marie Curie (UPMC, Paris 06), Paris, France;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm UMR_S 937, ICAN Institute, Université Pierre et Marie Curie (UPMC, Paris 06), Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Pierre-et-Marie-Curie</orgName>
</affiliation>
</author>
<author><name sortKey="Morange, Pierre Emmanuel" sort="Morange, Pierre Emmanuel" uniqKey="Morange P" first="Pierre-Emmanuel" last="Morange">Pierre-Emmanuel Morange</name>
<affiliation wicri:level="4"><nlm:aff id="aff74">Inserm UMR_S 626, Université de la Méditerranée, Marseille, France;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm UMR_S 626, Université de la Méditerranée, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
<settlement type="city">Marseille</settlement>
</placeName>
<orgName type="university">Université de la Méditerranée</orgName>
</affiliation>
</author>
<author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name>
<affiliation wicri:level="3"><nlm:aff id="aff29">Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name>
<affiliation wicri:level="1"><nlm:aff id="aff7">Wellcome Trust Sanger Institute, Hinxton, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton</wicri:regionArea>
<wicri:noRegion>Hinxton</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff25">Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research & Genetic Epidemiology, King's College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name>
<affiliation wicri:level="3"><nlm:aff id="aff59">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name>
<affiliation wicri:level="2"><nlm:aff id="aff75">Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff76">Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="O Donnell, Christopher J" sort="O Donnell, Christopher J" uniqKey="O Donnell C" first="Christopher J." last="O'Donnell">Christopher J. O'Donnell</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">National Heart, Lung, and Blood Institute (NHBLI) Framingham Heart Study, Framingham, MA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>National Heart, Lung, and Blood Institute (NHBLI) Framingham Heart Study, Framingham</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff10">Division of Intramural Research, NHLBI, Bethesda, MD;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Division of Intramural Research, NHLBI, Bethesda</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff77">Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name>
<affiliation wicri:level="3"><nlm:aff id="aff2">Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden;</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Blood</title>
<idno type="ISSN">0006-4971</idno>
<idno type="eISSN">1528-0020</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>We conducted a genome-wide association study to identify novel associations between genetic variants and circulating plasminogen activator inhibitor-1 (PAI-1) concentration, and examined functional implications of variants and genes that were discovered. A discovery meta-analysis was performed in 19 599 subjects, followed by replication analysis of genome-wide significant (<italic>P</italic>
< 5 × 10<sup>−8</sup>
) single nucleotide polymorphisms (SNPs) in 10 796 independent samples. We further examined associations with type 2 diabetes and coronary artery disease, assessed the functional significance of the SNPs for gene expression in human tissues, and conducted RNA-silencing experiments for one novel association. We confirmed the association of the 4G/5G proxy SNP rs2227631 in the promoter region of <italic>SERPINE1</italic>
(7q22.1) and discovered genome-wide significant associations at 3 additional loci: chromosome 7q22.1 close to <italic>SERPINE1</italic>
(rs6976053, discovery <italic>P</italic>
= 3.4 × 10<sup>−10</sup>
); chromosome 11p15.2 within <italic>ARNTL</italic>
(rs6486122, discovery <italic>P</italic>
= 3.0 × 10<sup>−8</sup>
); and chromosome 3p25.2 within <italic>PPARG</italic>
(rs11128603, discovery <italic>P</italic>
= 2.9 × 10<sup>−8</sup>
). Replication was achieved for the 7q22.1 and 11p15.2 loci. There was nominal association with type 2 diabetes and coronary artery disease at <italic>ARNTL</italic>
(<italic>P</italic>
< .05). Functional studies identified <italic>MUC3</italic>
as a candidate gene for the second association signal on 7q22.1. In summary, SNPs in <italic>SERPINE1</italic>
and <italic>ARNTL</italic>
and an SNP associated with the expression of <italic>MUC3</italic>
were robustly associated with circulating levels of PAI-1.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>France</li>
<li>Italie</li>
<li>Pakistan</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Angleterre de l'Est</li>
<li>Bade-Wurtemberg</li>
<li>Bavière</li>
<li>Californie</li>
<li>Caroline du Nord</li>
<li>District de Darmstadt</li>
<li>District de Fribourg-en-Brisgau</li>
<li>District de Haute-Bavière</li>
<li>District de Karlsruhe</li>
<li>District de Münster</li>
<li>District de Tübingen</li>
<li>East Middle Sweden</li>
<li>Grand Londres</li>
<li>Groningue (province)</li>
<li>Hesse (Land)</li>
<li>Hollande-Méridionale</li>
<li>Maryland</li>
<li>Massachusetts</li>
<li>Minnesota</li>
<li>New Hampshire</li>
<li>Nouvelle-Galles du Sud</li>
<li>Oxfordshire</li>
<li>Pennsylvanie</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Rhénanie-du-Nord-Westphalie</li>
<li>Svealand</li>
<li>Utrecht (province)</li>
<li>Vermont</li>
<li>Virginie</li>
<li>Washington (État)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Cambridge</li>
<li>Francfort-sur-le-Main</li>
<li>Fribourg-en-Brisgau</li>
<li>Groningue</li>
<li>Leyde</li>
<li>Londres</li>
<li>Mannheim</li>
<li>Marseille</li>
<li>Munich</li>
<li>Münster</li>
<li>Oxford</li>
<li>Paris</li>
<li>Rotterdam</li>
<li>Stockholm</li>
<li>Sydney</li>
<li>Tübingen</li>
<li>Ulm</li>
<li>Uppsala</li>
<li>Utrecht</li>
</settlement>
<orgName><li>Université Pierre-et-Marie-Curie</li>
<li>Université d'Oxford</li>
<li>Université d'Ulm</li>
<li>Université d'Uppsala</li>
<li>Université de Cambridge</li>
<li>Université de Sydney</li>
<li>Université de la Méditerranée</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Matijevic, Nena" sort="Matijevic, Nena" uniqKey="Matijevic N" first="Nena" last="Matijevic">Nena Matijevic</name>
<name sortKey="Williams, Scott M" sort="Williams, Scott M" uniqKey="Williams S" first="Scott M." last="Williams">Scott M. Williams</name>
</noCountry>
<country name="États-Unis"><region name="Massachusetts"><name sortKey="Huang, Jie" sort="Huang, Jie" uniqKey="Huang J" first="Jie" last="Huang">Jie Huang</name>
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<name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name>
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<name sortKey="Ding, Jingzhong" sort="Ding, Jingzhong" uniqKey="Ding J" first="Jingzhong" last="Ding">Jingzhong Ding</name>
<name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R." last="Folsom">Aaron R. Folsom</name>
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<name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D." last="Johnson">Andrew D. Johnson</name>
<name sortKey="Kathiresan, Sekar" sort="Kathiresan, Sekar" uniqKey="Kathiresan S" first="Sekar" last="Kathiresan">Sekar Kathiresan</name>
<name sortKey="Kathiresan, Sekar" sort="Kathiresan, Sekar" uniqKey="Kathiresan S" first="Sekar" last="Kathiresan">Sekar Kathiresan</name>
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<name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name>
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<name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name>
<name sortKey="Meigs, James B" sort="Meigs, James B" uniqKey="Meigs J" first="James B." last="Meigs">James B. Meigs</name>
<name sortKey="Meigs, James B" sort="Meigs, James B" uniqKey="Meigs J" first="James B." last="Meigs">James B. Meigs</name>
<name sortKey="Moore, Jason H" sort="Moore, Jason H" uniqKey="Moore J" first="Jason H." last="Moore">Jason H. Moore</name>
<name sortKey="Mychaleckyj, Josyf C" sort="Mychaleckyj, Josyf C" uniqKey="Mychaleckyj J" first="Josyf C." last="Mychaleckyj">Josyf C. Mychaleckyj</name>
<name sortKey="O Donnell, Christopher J" sort="O Donnell, Christopher J" uniqKey="O Donnell C" first="Christopher J." last="O'Donnell">Christopher J. O'Donnell</name>
<name sortKey="O Donnell, Christopher J" sort="O Donnell, Christopher J" uniqKey="O Donnell C" first="Christopher J." last="O'Donnell">Christopher J. O'Donnell</name>
<name sortKey="O Donnell, Christopher J" sort="O Donnell, Christopher J" uniqKey="O Donnell C" first="Christopher J." last="O'Donnell">Christopher J. O'Donnell</name>
<name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name>
<name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name>
<name sortKey="Reilly, Muredach P" sort="Reilly, Muredach P" uniqKey="Reilly M" first="Muredach P." last="Reilly">Muredach P. Reilly</name>
<name sortKey="Smith, Nicholas L" sort="Smith, Nicholas L" uniqKey="Smith N" first="Nicholas L." last="Smith">Nicholas L. Smith</name>
<name sortKey="Smith, Nicholas L" sort="Smith, Nicholas L" uniqKey="Smith N" first="Nicholas L." last="Smith">Nicholas L. Smith</name>
<name sortKey="Smith, Shelly" sort="Smith, Shelly" uniqKey="Smith S" first="Shelly" last="Smith">Shelly Smith</name>
<name sortKey="Tang, Weihong" sort="Tang, Weihong" uniqKey="Tang W" first="Weihong" last="Tang">Weihong Tang</name>
<name sortKey="Taylor, Kent" sort="Taylor, Kent" uniqKey="Taylor K" first="Kent" last="Taylor">Kent Taylor</name>
<name sortKey="Tracy, Russell P" sort="Tracy, Russell P" uniqKey="Tracy R" first="Russell P." last="Tracy">Russell P. Tracy</name>
<name sortKey="Yanek, Lisa R" sort="Yanek, Lisa R" uniqKey="Yanek L" first="Lisa R." last="Yanek">Lisa R. Yanek</name>
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<name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name>
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<name sortKey="Franco Cereceda, Anders" sort="Franco Cereceda, Anders" uniqKey="Franco Cereceda A" first="Anders" last="Franco-Cereceda">Anders Franco-Cereceda</name>
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<name sortKey="Sennblad, Bengt" sort="Sennblad, Bengt" uniqKey="Sennblad B" first="Bengt" last="Sennblad">Bengt Sennblad</name>
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<name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W." last="Asselbergs">Folkert W. Asselbergs</name>
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<name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name>
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<name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
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<name sortKey="Schrijvers, Elisabeth M C" sort="Schrijvers, Elisabeth M C" uniqKey="Schrijvers E" first="Elisabeth M. C." last="Schrijvers">Elisabeth M. C. Schrijvers</name>
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<name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
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<name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name>
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<name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E." last="Kleber">Marcus E. Kleber</name>
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<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Tofler, Geoffrey H" sort="Tofler, Geoffrey H" uniqKey="Tofler G" first="Geoffrey H." last="Tofler">Geoffrey H. Tofler</name>
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<country name="Pakistan"><noRegion><name sortKey="Saleheen, Danish" sort="Saleheen, Danish" uniqKey="Saleheen D" first="Danish" last="Saleheen">Danish Saleheen</name>
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<country name="Italie"><noRegion><name sortKey="Franzosi, Maria Grazia" sort="Franzosi, Maria Grazia" uniqKey="Franzosi M" first="Maria Grazia" last="Franzosi">Maria Grazia Franzosi</name>
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</record>
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